Sedum alkaloids

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Total synthesis of sedum alkaloids via catalyst controlled aza-Cope rearrangement and hydroformylation with formaldehyde.

The catalytic asymmetric aminoallylation of chiral aldehydes is developed as a new method for the catalyst controlled synthesis of syn- and anti-1,3-aminoalcohols. This methodology is highlighted in the synthesis of the sedum alkaloids (+)-sedridine and (+)-allosedridine both of which have their final carbon incorporated during closure of the piperidine ring via a hydroformylation with formalde...

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ژورنال

عنوان ژورنال: Chemistry of Natural Compounds

سال: 1977

ISSN: 0009-3130,1573-8388

DOI: 10.1007/bf00565860